Endocrine Abstracts

Introduction: Graves orbitopathy (GO) is an inflammatory condition of the orbital fat and muscles and affect 30-50% of patients with Graves’ disease. The first-line treatment of moderate to severe GO according to EUGOGO is intravenous glucocorticoids, but 20-30% of the cases appear to be corticosteroid resistant or refractory. Promising results have been described with Tocilizumab (TCZ) as a second-line moderate to severe GO treatment.Case presentat...

Introduction: Graves’ Orbitopathy (GO), the most common extrathyroidal manifestation of Graves’ disease (GD), usually presents bilateral disease. However, a minority of patients present with unilateral disease, the prevalence of which is between 4,5% and 14%. The aim of our study is to evaluate the specific demographic and clinical characteristics and potential differences between bilateral and unilateral GO, and the association with disease activity and severity.</p...

Background: The majority of adrenal incidentalomas (AIs) are benign non-functioning adrenocortical adenomas (NFAIs), yet not clinically silent. Possible autonomous cortisol secretion (PACS) can also be diagnosed in up to 50% of patients. Endocannabinoids (ECs) have recently been studied regarding their role in the hypothalamo-pituitary-adrenocortical (HPA) axis; however, data are scarce in humans.Aim: We aimed to assess hair EC [anandamide (AEA) and 2-ar...

IntroductionA strong association between autoimmune atrophic gastritis and other autoimmune disorders has been well documented. The prevalence of gastric mucosa alterations in patients with thyroid autoimmunity is not well known. The aim of our study was to assess the prevalence of intestinal metaplasia in patients with Graves’ disease (GD) and positive anti-parietal cell antibodies (APCA).Methods<p class=...

IntroductionJacobsen syndrome (JS) is a rare gene disorder caused by a terminal deletion of the long arm of chromosome 11. The estimated prevalence of Jacobsen syndrome is 1/100.000 births. It is most commonly presented with psychomotor and physical growth retardation, dysmorphic facial features, thrombocytopenia or pancytopenia. It is also characterized by congenital heart defects, and kidney, gastrointestinal tract, genitalia, CNS and skeletal deformit...

IntroductionGraves’ disease (GD) is an autoimmune thyroiditis frequently associated with development of Graves’ orbitopathy (GO). Diplopia (double vision) is a major determinant of work disability in patients with GO. The aim of our study was to assess the prevalence of diplopia and strabismus in patients with GO.MethodsThis is a single-center observational study in an outpatient clinic of autoimmun...

Background: Immune checkpoint inhibitors (ICIs) constitutes a novel treatment for patients with melanoma. Endocrine-related adverse effects are now a distinctive clinical entity of ICIs, with hypophysitis and thyroiditis being the most common. Recent consensus doesn’t suggest routinely screening of bone mass indexes in patients on ICIs since data in the literature are scarce.Methods: Data regarding bone disease were retrospectively analysed in 118 p...

Background: Immune checkpoint inhibitors (ICIs) (anti-CTLA-4, PD-1 inhibitors, PD-L1 inhibitors) are considered a widely used therapeutic choice for several cancer types. However ICI therapy is frequently complicated by adverse events; endocrine toxicities are the most common ones.Methods: To assess in a retrospective observational study in a tertiary hospital the incidence and the characteristics of the immunotherapy-related endocrine adverse events (ir...